ANALGESICS: USES, TREATMENT, RISKS- STUDSAVER
ANALGESICS 1. Non-steroidal anti-inflammatory drugs (NSAIDs) (i) Non-selective e.g. ibuprofen, diclofenac , naproxen, salicylates (aspirin) etc (ii) Selective COX-2 inhibitors e.g. celecoxib, aceclofenac 2. Narcotic analgesics/opiates /opioids e.g. morphine, pethidine, tramadol, codeine, oxycodone etc 3. Miscellaneous e.g. acetaminophen (paracetamol) COX-enzymes •COX-1 is present in all tissues and cell types. It is involved in blood clot and protects the stomach lining. •COX-2 is produced at the sites of trauma or injury (inducible) . It is associated with pain and other signs of inflammation. •COX-3 is present in the CNS and it is associated with pain and fever. NSAIDs Therapeutic effects of NSAIDS •Suppression of inflammation: Initial drug of choice for rheumatoid arthritis. •Analgesia: Drug of choice for mild to moderate pain e.g. headache, toothache etc. •Reduction of fever: Reduces fever by inhibi...